Boosting the Productivity of H2-Driven Biocatalysis in a Commercial Hydrogenation Flow Reactor Using H2 From Water Electrolysis

Translation of redox biocatalysis into a commercial hydrogenation flow reactor, with in-built electrolytic H 2 generation, was achieved using immobilized enzyme systems. Carbon-supported biocatalysts were first tested in batch mode, and then transferred continuous columns for -driven, NADH-dependent asymmetric ketone reductions. The thus handled comparably to heterogeneous metal catalysts, but operated at room temperature 1–50 bar , highlighting that biocatalytic strategies enable implementation reactions under mild–moderate conditions. Continuous demonstrated as strategy process intensification; high conversions short residence times, biocatalyst turnover frequency productivity. These results show the prospect enzymes reactor infrastructure designed conventional hydrogenations.